A study on the metabolism of glyoxal in vitro.
نویسنده
چکیده
It was found by Kisch (1) that methylglyoxal inhibits tissue respiration in vitro. The mechanism of this inhibition is the combination of methylglyoxal with enzyme proteins, requiring -SH groups for their catalytic activity (2). As a continuation of these experiments, the specificity of the widely distributed glyoxalase-glutathione (GSH) system was tested with both methylglyoxal and glyoxal. This study in turn led to the characterization of the biochemical action and detoxification of glyoxal.
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 194 2 شماره
صفحات -
تاریخ انتشار 1952